30th Annual International AF Symposium™
Scientific Program 2025
This intensive three-day symposium brings together the world's leading medical scientists to share the most recent advances
in the field of atrial fibrillation in a highly interactive environment.
THURSDAY, JANUARY 16, 2025
7:00-7:30 AM Welcome and Introduction
7:30-8:30 AM
New Trends in Managing the AF Epidemic
Moderators: Nassir Marrouche, MD and Mina Chung, MD
All lectures 7 minutes. Panel and Audience Discussion 25 minutes.
The Role of GLP1 Agonists in Patients with Atrial Fibrillation
Donna Ryan, MD
GLP-1 Agonists & Epicardial Adipose Tissue: Impact on AF
Gianluca Iacobellis, MD, PhD
Screening for AF: Differential Risk Factors and Outcomes for Asymptomatic vs. Symptomatic AF
Christine Albert, MD
Digital Health for AF Detection and Management: Boon or Bust?
Rod Passman, MD
Leveraging Novel Data Types to Estimate Atrial Fibrillation Risk
Shaan Khurshid, MD
Panel and Audience Discussion (25 minutes) - All Faculty and Natalia Trayanova, PhD
8:30-9:30 AM
Spotlight Session – New and Emerging Technologies in Arrhythmia Management
Moderator: Kenneth Ellenbogen, MD
All lectures 5 minutes. FDA Presentation 7 minutes.
AF Ablation Using a Novel Coherent Sine Burst Pulsed Field System: Acute and 90-Day Remapping Results (Arga Medtech)
Ante Anic, MD
First Clinical Experience with the BTL EasyPulz System for AF Ablation
(BTL Medical)
Vivek Reddy, MD
Esophageal Cooling During RF Ablation: Clinical Evidence and Workflow Considerations (Haemonetics)
Mark Metzl, MD
Cardio-Sleep Platforms to Co-Manage Sleep Apnea in Patients with AF (Huxley Medical)
Devi Nair, MD
Advanced 3D Navigation and Imaging for True Anatomical Guidance in a New Era of Cardiac Therapies (LumaVision)
Shephal Doshi, MD
Pulsed Field Ablation with Integrated Metabolic Feedback for Lesion Assessment and Gap Mapping (LuxMed Systems)
Timothy Maher, MD
Closed-loop Non-invasive Neuromodulation & Monitoring System for the Treatment of Atrial Fibrillation (CardiaCare)
Vivek Reddy, MD
AcuNav Lumos 4D ICE Workflow in Concomitant AF Ablation and LAAC Procedures (Siemens Healthineers)
Amin Al-Ahmad, MD
The Importance of Trigger Mapping in AF
(Vektor Medical)
Anish Amin, MD
Volta Medical and PFA - An Optimized Strategy for Repeat Catheter Ablations
(Volta Medical)
Devi Nair, MD
FDA Perspective on Evaluation of New Technologies for AF Ablation: A Changing Landscape
Jun Dong, MD
9:30-10:00 AM Break
10 AM-12:30 PM
Case Transmissions Session 1
Moderator: Moussa Mansour, MD
Panel: Claudio Tondo, MD, PhD, Roland Tilz, MD, Christopher Ellis, MD, Andrea Natale, MD, Devi Nair, MD, Vivek Reddy, MD, & Jacqueline Saw, MD
WATCHMAN Left Atrial Appendage Closure Using the TrueSteer Access System
Bradley Mikaelian, MD (Univ Colorado, Colorado Springs, CO)
Concomitant AF Ablation with Amulet LAAO
Dhanunjaya R. Lakkireddy, MD (Kansas City Heart Institute, Overland Park, KS)
Left Atrial Appendage Closure With the LAMINARLAA Device
Devi Nair, MD (St. Bernards Healthcare, Jonesboro, AR)
Concomitant Ablation of AF Using the FARAWAVE Pentaspline PFA Catheter and WATCHMAN LAA Closure
Rodney Horton, MD & Weeranun Bode, MD (Texas Cardiac Arrhythmia Institute, Austin, TX)
Elimination of the Left Atrial Appendage by Invagination and Ligation with a Novel Transcatheter System
Vivek Reddy, MD and Petr Neuzil, MD, PhD (Homolka Hospital, Prague, Czech Republic)
12:30-1:30 PM Lunch
1:30-2:30 PM
Case Transmissions Session 2
Moderator: Moussa Mansour, MD
Panel: Andrea Natale, MD, Andrea Russo, MD, Luigi Di Biase, MD, PhD, Tina Baykaner, MD, & Gerhard Hindricks, MD, PhD
Ablation of Paroxysmal AF Using the VARIPULSE Variable Loop Circular PFA Catheter
Dhanunjaya R. Lakkireddy, MD (Kansas City Heart Institute, Overland Park, KS)
Concomitant Ablation of PAF Using the VARIPULSE Variable Loop Circular PFA Catheter and LAA Closure Using NUVISION Guidance
Rodney Horton MD & Weeranun Bode, MD (Texas Cardiac Arrhythmia Institute, Austin, TX)
2:30-3:30 PM
Stroke Risk Management in Atrial Fibrillation Session I
Moderators: Daniel Singer, MD and Mina Chung, MD
All lectures 7 minutes. Panel and Audience Discussion 25 minutes.
Anticoagulation in Low Risk Patients with AF - Impact on Stroke on Cognitive Function
Lena Rivard, MD
Management of Device-Detected AF - Implications of ARTESIA and NOAH-AFNET 6 Trials
Andreas Rillig, MD
Current Status of Factor XIa Inhibitors for AF Post OCEANIC-AF Trial
Jonathan Piccini, MD, MHS
Anticoagulation Strategies After Left Atrial Appendage Closure 2025
Walid Saliba, MD
Stroke Prevention Following Catheter Ablation for AF: Patient Selection for LAA Closure - Insights from the OPTION Study
Oussama Wazni, MD
Panel and Audience Discussion (25 minutes) – All Faculty
3:30-4:30 PM
Stroke Risk Management in Atrial Fibrillation Session II
Supported by an Educational Grant from Boston Scientific
Moderators: Devi Nair, MD and Jacqueline Saw, MD
All lectures 7 minutes. Panel and Audience Discussion 25 minutes.
Procedural Methods to Avoid Leaks During Implantation with LAA Closure Devices
Christopher Ellis, MD
Predictors of and Strategies for Avoiding Complications with LAA Closure Procedures
James Freeman, MD
ICE Guided LAA Closure - Extent of Use and Limitations
Shephal Doshi, MD
Future Directions in LAA Closure Devices and Enabling Technologies
Vivek Reddy, MD
Strategies for Accelerating Approval of Stroke Prevention Devices - Alternative Endpoints
Aneesh Deoras, MSE
Panel and Audience Discussion (25 minutes) - All Faculty
4:30 – 5:00 PM Break
Thursday continues >>>
THURSDAY CONTINUED
5:00 – 6:30 PM
Late Breaking Clinical Science Session I
Moderators: Luigi Di Biase, MD, PhD and Kalyanam Shivkumar, MD, PhD
All lectures 7 minutes. Panel Discussion 25 minutes.
Safety and Efficacy of Pulsed Field Ablation for Persistent Atrial Fibrillation: One-Year Results of ADVANTAGE AF
Vivek Reddy, MD
Comparison of Left Atrial Appendage Closure and Oral Anticoagulation After Catheter Ablation for Atrial Fibrillation: Concomitant and Sequential Cohorts of the OPTION Randomized Controlled Trial
Walid Saliba, MD
Artificial Intelligence-guided Spatio-temporal Dispersion Adjudication Based on Purported AF Source Dynamics: Clinical Evidence of Stable AF Sources in Persistent AF Patients
Clément Bars, MD
Left Atrial Appendage Elimination by Vacuum-Based Invagination and Ligation: A First-in-Human Clinical Experience
Vivek Reddy, MD
Early vs Late Atrial Fibrillation Recurrence After Pulsed Field Ablation: Insights From the admIRE Trial
Luigi Di Biase, MD, PhD
Invasive Remapping to Assess Long Term Durability of Pulmonary Vein Isolation for Pulsed Field Ablation with Zero Fluoroscopy Approach
Devi Nair, MD
Feasibility of a Novel Automatic Segmentation and Machine Learning Tool for Outcome Prediction in Persistent Atrial Fibrillation Using Real World Data
Ayman Hussein, MD
7:00 - 9:00 PM
Reception for All Attendees, Industry, and Faculty
Location: Seaport Hotel Boston
1 Seaport Lane, Boston, MA
FRIDAY, JANUARY 17, 2025
7:00-7:30 AM Welcome and Introduction
7:30-8:30 AM
Endpoints and Outcomes of Catheter Ablation for Atrial Fibrillation
Moderators: Gerhard Hindricks, MD, PhD and Douglas Packer, MD
All lectures 7 minutes. Q&A, Panel and Audience Discussion 25 minutes.
Catheter Ablation for AF - Impact On Clinical Outcomes 2025
Rui Providencia, MD, PhD
Optimal Timing of Catheter Ablation for Nonparoxysmal AF
Jason Andrade, MD
Evolving Evidence on Catheter Ablation of AF in Patients with Severe Heart Failure
Philipp Sommer, MD
Redefining the Blanking Period After Catheter Ablation for AF
Nassir Marrouche, MD
Endpoints of AF Ablation - AF Burden vs Time to First Recurrence of AF
Kenneth Ellenbogen, MD
Panel and Audience Discussion (25 minutes) – All Faculty
8:30-9:30 AM
Case Transmissions Session 3
Moderator: Moussa Mansour, MD
Panel: Andrea Sarkozy, MD, PhD, Hugh Calkins, MD, Boris Schmidt, MD, Vivek Reddy, MD, David Keane, MD, PhD & Laurent Macle, MD
Redo Ablation of Atrial Fibrillation Using the SPHERE 9 Lattice Tip PFA Catheter
Srinivas Dukkipati, MD & Daniel Musikantow, MD (Mount Sinai Medical Center, New York, NY)
PVI and Posterior Wall Ablation for Persistent AF Using the FARAVIEW Technology
Kevin Heist, MD, William Hucker, MD, PhD, & Dingxin Qin, MD (Massachusetts General Hospital, Boston, MA)
9:30-10:00 AM Break
10:00 AM-12:30 PM
Case Transmissions Session 4
Moderator: Moussa Mansour, MD
Panel: Boris Schmidt, MD, Andrea Sarkozy, MD, PhD, Andrea Natale, MD, Tina Baykaner, MD, Tom De Potter, MD,
Luigi Di Biase, MD, PhD, & Vivek Reddy, MD
FARAWAVE PFA Catheter for Cavotricuspid Isthmus Ablation - PROSPECT IDE Study
Jacob Koruth, MD and Srinivas Dukkipati, MD (Mount Sinai Medical Center, New York, NY)
PVI and Posterior Wall Ablation Using the VARIPULSE Variable Loop Circular PFA Catheter - POLARIS Study
Greg Michaud, MD (Beth Israel Deaconess Medical Center, Boston, MA)
TactiFlex Duo Dual Modality RF/PFA Ablation for PAF - the FlexPulse IDE Trial
Larry Chinitz, MD (NYU Langone Health Center, New York, NY)
Ablation of Paroxysmal AF Using the PulseSelect Circular PFA Catheter
Stavros Mountantonakis, MD, MBA (Lenox Hill Hospital, New York, NY)
Ablation of Persistent Atrial Fibrillation Using the SPHERE 9 Lattice Tip PFA Catheter
Amin Al-Ahmad, MD & Weeranun Bode, MD (Texas Cardiac Arrhythmia Institute, Austin, TX)
12:30-1:30 PM Lunch
1:30-2:30 PM
Lesion Assessment in Catheter Ablation for Atrial Fibrillation
Supported by an Educational Grant from Johnson & Johnson MedTech
Moderators: Devi Nair, MD and Luigi
Di Biase, MD, PhD
All lectures 7 minutes. Panel Discussion 25 minutes.
Tools for Prediction of Ablation Lesion Depth
Hiroshi Nakagawa, MD, PhD
Durability of Dual Energy Focal AF Ablation: Evidence from Remapping Studies
Matthias Duytschaever, MD
Predictors of Success of Pulmonary Vein Isolation with Pulsed-Field Ablation Using a Variable-Loop Circular Catheter
Tom De Potter, MD
Future Directions in Maximizing Lesion Depth - Combined RF and PF Ablation
Atul Verma, MD
No Fluoroscopy Pulsed Field Ablation for AF
Will Sauer, MD
Panel and Audience Discussion - All Faculty
2:30-3:30 PM
Catheter Ablation for Persistent Atrial Fibrillation: Beyond PVI
Supported by an Educational Grant from Medtronic
Moderators: Melanie Gunawardene, MD and Atul Verma, MD
All lectures 7 minutes. Panel Discussion 25 minutes.
Ablation for Persistent AF: Results of Multicenter IDE Studies
Devi Nair, MD
Impact of and Patient Selection for Posterior Wall Ablation for Persistent AF
Andrea Natale, MD
Mitral Isthmus, CTI, SVC, and Fibrotic Regions Ablation for Persistent AF
Tyler Taigen, MD
Pulsed Field Ablation for Redo Procedures in Patients with Persistent AF
Andrea Sarkozy, MD, PhD
Advances in Mapping of Atrial Fibrillation - The Next Frontier in AF Management
Vivek Reddy, MD
Panel and Audience Discussion (25 minutes): All Faculty
3:30-4:00 PM Break
Friday continues >>>
FRIDAY CONTINUED
4:00-5:30 PM
Case Transmissions Session 5
Moderators: Moussa Mansour, MD
Panel: Boris Schmidt, MD, Claudio Tondo, MD, PhD, Mattias Duytschaever, MD, Vivek Reddy, MD, Pierre Jais, MD, Melanie Gunawardene, MD, & Luigi Di Biase, MD, PhD
PVI for Paroxysmal AF Using the FARAVIEW Technology
Wilber Su, MD (University of Arizona, Phoenix, AZ)
Ablation of Paroxysmal AF Using the OMNYPULSE Novel Large Footprint Focal Force Sensing PFA Catheter
Moussa Mansour, MD (Massachusetts General Hospital, Boston, MA)
PVI and CTI Ablation for AF Using the Globe Pulsed Field Ablation Catheter
Vivek Reddy, MD & Petr Neuzil, MD, PhD (Homolka Hospital, Prague, Czech Republic)
5:30-7:00 PM
Late Breaking Clinical Science Session II and Best Abstract Award
Moderators: Kalyanam Shivkumar, MD, PhD and Luigi Di Biase, MD, PhD
All talks 7 minutes & 3 minutes Q&A
Insights from Re-Do Procedures After Pulsed Field Ablation for Atrial Fibrillation: A MANIFEST-PF Registry Sub-Study (MANIFEST-REDO)
Daniel Scherr, MD
Acute Results Demonstrate Safety and Effectiveness of Balloon-based Pulsed Field Ablation System for de novo PVI in PAF and PersAF
Roland Tilz, MD
MANIFEST-SPASM: A Coronary Spasm
Sub-Study of MANIFEST-17K
Emmanuel Ekanem, MD
Pulse Field Ablation Using A Compliant Circular Catheter Delivering Nanosecond Pulses To Treat Atrial Fibrillation
Vivek Reddy, MD
Impact of Catheter Ablation on Functional Outcomes in Patients with Atrial Fibrillation-Related Stroke: The RESCUE-STROKE Study
Dhanunjaya Lakkireddy, MD
Ability of Real Time Tissue Optical Assessment to Predict Lesion Durability: First in Human Study
Atul Verma, MD
Premature Ventricular Complexes (PVCs) After Catheter Ablation for Paroxysmal Atrial Fibrillation (PAF) Predict Recurrent Atrial Arrhythmias: Results from admIRE
William Whang, MD
Best Abstract Award
7:00 PM Adjourn
SATURDAY, JANUARY 18, 2025
7:00-7:30 AM Welcome and Introduction
7:30 AM-9:30 AM
Case Transmissions Session 6
Moderator: Moussa Mansour, MD
Panel: Meleze Hocini, MD, Suneet Mittal, MD, Vivek Reddy, MD, Josef Kautzner, MD, PhD, Ante Anic, MD, Young Hoon Kim, MD, PhD, & Bradley Knight, MD
Nanosecond Pulsed Field Ablation for Atrial Fibrillation
Petr Neuzil, MD, PhD (Homolka Hospital, Prague, Czech Republic)
Catheter Ablation for AF Using the FieldForce Pulsed Field Ablation Technology
Vivek Reddy, MD & Petr Neuzil, MD, PhD (Homolka Hospital, Prague, Czech Republic)
PVI for Paroxysmal AF Using the FARAWAVE PFA Catheter Without A Mapping System
Anish Amin, MD (OhioHealth Riverside Methodist Hospital, Columbus, OH)
Pulmonary Vein Isolation Using the SPHERE 360 Large Lattice Tip PFA Catheter
Josef Kautzner, MD, PhD (Heart Centre IKEM, Prague, Czech Republic)
9:30-10 AM: Break
10:00-11:00 AM
Case Transmissions Session 7
Moderator: Moussa Mansour, MD
Panel: Arash Aryana, MD, Isabel Deisenhofer, MD, Larry Chinitz, MD, Suneet Mittal, MD, & Meleze Hocini, MD
Ablation of PAF with the Volt Balloon in Basket PFA System – the Volt-AF IDE Trial
Gianbattista Chierchia, MD, PhD (Heart Rhythm Management Ctr., Brussels, Belgium)
Ablation of PAF Using the Dual Energy Pulsed Field-Radiofrequency STSF Catheter
Larry Chinitz, MD (NYU Langone, New York, NY)
11:00 AM-12:00 PM
Catheter Design for Pulsed Field Ablation
Supported by an Educational Grant from Abbott
Moderators: Oussama Wazni, MD and Amin Al-Ahmad, MD
All lectures 7 minutes. Panel Discussion 25 minutes.
Impact of Waveform on Biological Effects of Pulsed Field Ablation
Atul Verma, MD
Impact of Contact on Lesion Quality of Pulsed Field Ablation for AF
Melanie Gunawardene, MD
Balloon-Based Pulsed Field Ablation Catheters
Gianbattista Chierchia, MD, PhD
Multi-Electrode vs Large Focal Catheters for Pulsed Field Ablation
Pierre Jais, MD
Role of Small Focal Dual Energy Pulsed Field Ablation Catheters
Dhanunjaya R. Lakkireddy, MD
Panel and Audience Discussion (25 minutes) – All Faculty
12:00-12:30 PM Working Lunch
12:30-1:30 PM
Pulsed Field Ablation – Safety, Efficiency and Workflow
Moderators: Edward Gerstenfeld, MD and Meleze Hocini, MD
All lectures 7 minutes. Panel Discussion 25 minutes.
Coronary Artery Injury with Pulsed Field Ablation
Melanie Gunawardene, MD
Safety Considerations with Pulsed Field Ablation - Cerebral Lesions
Walid Saliba, MD
Safety Considerations with Pulsed Field Ablation - Hemolysis
Pierre Jais, MD
Tissue Selectivity of Pulsed Field Ablation: Mechanisms of Esophageal Sparing
Vivek Reddy, MD
Efficiency of Pulsed Field Ablation - Workflow and Level of Anesthesia
Ante Anic, MD
Panel and Audience Discussion (25 minutes) - All Faculty
1:30-3:00 PM
Case Transmissions Session 8
Moderator: Moussa Mansour, MD
Panel: Devi Nair, MD, Hans Kottkamp, MD, Atul Verma, MD, David Keane, MD, PhD, Vivek Reddy, MD, & Laurent Macle, MD
Visually-Guided PVI with the OptiShot PFA Balloon Catheter
Vivek Reddy, MD and Petr Neuzil, MD, PhD (Homolka Hospital, Prague, Czech Republic)
PVI and Fibrosis Ablation for AF Using the Globe Pulsed Field Ablation Catheter
Hans Kottkamp, MD (Westpfalz-Klinikum Hospital, Kaiserslautern, Germany)
Ablation of Persistent AF Using the PulseSelect Circular PFA Catheter
Devi Nair, MD (St. Bernards Healthcare, Jonesboro, AR)
3:00-4:00
Challenging Cases in AF Management and Stroke Prevention
(7-minute presentation & 5-minute discussion for each case)
Moderator: David Keane, MD, PhD
Faculty: Francis Marchlinski, MD, John Day, MD, Isabel Deisenhofer, MD, Edward Gerstenfeld, MD, & Young-Hoon Kim, MD, PhD
4:00 ADJOURN