Twenty-ninth Annual International AF Symposium Scientific Program 2024

7:15 AM Welcome and Introduction

7:30-8:30 AM
New Trends in Managing the AF Epidemic Moderators: Nassir Marrouche, MD and Natalia Trayanova, PhD, MS
All lectures 7 minutes. Panel and Audience Discussion 25 minutes.

Advances in Achieving Sustainable Weight Loss and Implications for Health Outcomes
Donna Ryan, MD

Comparison of Consumer Wearable Smart Devices for AF Detection
Sana Al-Khatib, MD

Advances in Artificial Intelligence for the Prediction, Detection, and Treatment of Atrial Fibrillation
Shaan Khurshid, MD

Machine Learning for Prediction of Atrial Fibrillation Ablation Outcomes
Tina Baykaner, MD

Role of Technology in Addressing Inequities in AF Management
Kevin Thomas, MD

Panel and Audience Discussion (25 minutes) – All Faculty

8:30-9:30 AM
Spotlight Session I – New and Emerging Technologies in Arrhythmia Management
Moderator: Paul Wang, MD
All lectures 5 minutes. FDA Presentation 7 minutes.

IV Sotalol for Atrial Fibrillation – Insights from the PEAKS Registry (AltaThera Pharmaceuticals)
Jared Bunch, MD

A Novel PFA Platform – Using a Multipurpose Catheter and Coherent Sine Wave Burst (CSE) for AF Ablation – Initial Experience from the FIH Trial (Arga MedtechSteradian Shield)
Ante Anic, MD

Proactive Esophageal Cooling – Data Update and Overview (Attune Medical)
Dinesh Sharma, MD

3D Navigation & AI Enabled Mapping for Pulsed Field Ablation (CardioNXT)
Anil Rajendra, MD

Vascular Closure System – Early Ambulation, Workflow, Efficiencies, & Patient Satisfaction (Haemonetics)
Larry Chinitz, MD

Intranasal Etripamil in AF-RVR: Data on Efficacy for Acute Rate Control (Milestone Pharmaceuticals)
Jonathan Piccini, MD

First Clinical Experience Performing Ablations with SentiAR Holographic Guidance System (SentiAR)
Gregory Michaud, MD

Clinical Roadmap for Volta Medical’s AI Technology (Volta Medical)
Jose Osorio, MD

Multiflex Steerable Sheath to Facilitate Electrophysiology & Structural Heart Interventions (Vizaramed)
Devi Nair, MD

FDA Lecture: Effectiveness Evaluation for New Technologies in AF Ablation Device Trials
Jun Dong, MD, Medical Officer, Office of Cardiovascular Devices, CDRH, US FDA

9:30-10:00 AM Break

10 AM-12:30 PM
Case Transmissions Session 1
Moderator:
Moussa Mansour, MD
Panel:
Gerhard Hindricks, MD, Pierre Jais, MD, Andrea Natale, MD, Vivek Reddy, MD, Dhanunjaya Lakkireddy, MD

Ablation of PAF Using a Dual Energy Pulsed Field-Radiofrequency STSF Catheter
David Newton, MD (Savannah, GA)

PVI and Posterior Wall Ablation of Persistent AF Using FARAWAVE Pentaspline PFA Catheter
Moussa Mansour, MD (Boston, MA)

Pulmonary Vein Isolation Using SPHERE 360 Large Lattice Tip PFA Catheter
Petr Neuzil, MD, PhD and Vivek Reddy, MD (New York, NY)

Disc and Lobe LAA Closure using Amulet with ICE Guidance
Usman Siddiqui, MD (Orlando, FL)

LAA Closure with the Conformal Device
Christopher Ellis, MD (Nashville, TN)

12:30-1:30 PM Lunch

1:30-2:30 PM
Case Transmissions Session 2
Moderator: Moussa Mansour, MD
Panel: Luigi Di Biase, MD, PhD, Walid Saliba, MD, and Kenneth Ellenbogen, MD

WATCHMAN Left Atrial Appendage Closure with Single-Step Transseptal Access
Moussa Mansour, MD (Boston, MA)

PVI Using POLARx FIT Novel Expandable Cryoballoon with Single-Step Transseptal Access
Bradley Knight, MD (Northwestern Chicago)

2:30-3:30 PM
Stroke Risk Management in Atrial Fibrillation Session I
Moderators: Rod Passman, MD and Jonathan Piccini, MD
All lectures 7 minutes. Panel and Audience Discussion 25 minutes.

Anticoagulation in Patients with Implantable Device Detected Atrial High Rate Episodes NOAH-AFNET6 Trial/ARTESIA/other
Daniel Singer, MD

Factor XI/XIa Inhibitors – Mechanisms, Clinical Outcomes, and Future Directions
Elaine Hylek, MD

Outcome Severity with Falls on Anticoagulant Drugs vs LAA Closure Devices
Mingming Ning, MD, MSc

Stroke Severity with Different Stroke Prophylaxis Therapies: DOACs vs LAA Closure Devices
Mohit Turagam, MD

Single Antiplatelet Therapy with New Generation LAA Closure Devices
Walid Saliba, MD

Panel and Audience Discussion (25 minutes) – All Faculty

3:30-4:30 PM
Stroke Risk Management in Atrial Fibrillation Session II
Supported by an Educational Grant from Boston Scientific
Moderators: Walid Saliba, MD and
Devi Nair, MD

All lectures 7 minutes. Panel and Audience Discussion 25 minutes.

Safety and Efficacy of Watchman FLX: Real World Experience (SURPASS Registry)
James Freeman, MD

ICE Guided Left Atrial Appendage Closure
Shephal Doshi, MD

Peri-Device Leaks with LAA Closure Devices: What Does the Evidence Show?
Rodney Horton, MD

Concomitant Left Atrial Appendage Closure with Other Cardiac Procedures
Oussama Wazni, MD

New Devices for LAA Closure – Future Directions in Technology
Vivek Reddy, MD

Panel and Audience Discussion – All Faculty & Andrew Farb, MD, Chief Medical Officer, Office of Cardiovascular Devices, CDRH, US FDA

4:30 – 5:00 PM Break

5:00 – 6:00 PM
Improving Technologies and Workflows for Efficiency and Outcomes
Supported by an Educational Grant from Abbott
Moderators: Andrea Natale, MD and
John Day, MD

All lectures 7 minutes. Panel Discussion 25 minutes.

Long Term Outcomes of LAA Closure with a Disc and Lobe Occluder
DJ Lakkireddy, MD

Optimizing Efficacy and Safety of LAA Closure with a Disc and Lobe Occluder
Jacqueline Saw, MD

Advances in Localizing and Defining Arrhythmia Mechanisms – Impact of Omnipolar Peak Frequency Mapping
Jonathan Piccini, MD

Optimization of Radiofrequency Ablation with a Flexible Tip Contact Force Sensing Catheter
Larry Chinitz, MD

First in Human Experience with a Balloon-Based Pulsed Field Ablation System
Atul Verma, MD

Panel and Audience Discussion (25 minutes): All Faculty

This intensive three-day symposium brings together the world's leading medical scientists to share the most recent advances
in the field of atrial fibrillation in a highly interactive environment.

Please click on the title of each session to view each recorded session.


THURSDAY, FEBRUARY 1, 2024

THURSDAY CONTINUED

6:00-7:00 PM
Late Breaking Clinical Science Session I
Moderators:
Angelo Auricchio, MD, PhD and Kalyanam Shivkumar, MD, PhD
All talks 10 minutes & 5 minutes Q&A

Acute Kidney Injury Resulting From Hemoglobinuria Following Pulsed-Field Ablation In Atrial Fibrillation: Is It Preventable?
Andrea Natale, MD

Real-world Data Affirms Safety and Effectiveness of Low/Zero Fluoroscopy Atrial Fibrillation Ablation
Jose Osorio, MD

Impact of Left Atrial Posterior Wall Ablation During Pulsed Field Ablation for Persistent Atrial Fibrillation: A MANIFEST-PF Registry Sub-Study
Mohit Turagam, MD

Safety, Efficiency, and Accuracy of
Pre-procedural Predictive Modeling Using Artificial Intelligence Algorithm to Predict the Left Atrial Appendage Characteristics and the Appropriate Device Size for Closure
Devi Nair, MD

7:00 – 8:30 PM
Reception for All Attendees, Industry, and Faculty
Pre-Function Area Level 2 Outside Exhibit Hall

FRIDAY, FEBRUARY 2, 2024

7:15 AM Welcome and Introduction

7:30-8:30 AM
The Benefits of Ablation Across the AF Spectrum: From Early Intervention to Late-Stage Heart Failure
Moderators: Nassir Marrouche, MD and Oussama Wazni, MD
All lectures 7 minutes. Q&A, Panel and Audience Discussion 25 minutes.

Role of Catheter Ablation in Asymptomatic Atrial Fibrillation
Stephan Willems, MD

Impact of Ablation on AF Progression: Implications for Timing and Type of Ablation
Jason Andrade, MD

AF Ablation in Patients with Advanced Heart Failure: CASTLE-HTx
Philipp Sommer, MD

AF Ablation in Patients with Heart Failure and Preserved Ejection Fraction
Douglas Packer, MD

Medication vs Catheter Ablation for Initial Treatment of AF – Guidance for the Clinician
Francis Marchlinski, MD

Panel and Audience Discussion (25 minutes) – All Faculty

8:30-9:30 AM
Case Transmissions Session 3
Moderator: Moussa Mansour, MD
Panel: Pierre Jais, MD, Hugh Calkins, MD, Srinivas Dukkipati, MD, Julian Chun, MD

Concomitant AF Ablation with FARAWAVE Pentaslpine PFA Catheter and WATCHMAN LAA Closure
Claudio Tondo, MD, PhD (Milan, Italy)

Ablation of Atrial Fibrillation Using SPHERE 9 Lattice Tip PFA Catheter
Andreas Metzner, MD (Hamburg, Germany)

9:30-10:00 AM Break

10:00 AM-12:30 PM
Case Transmissions Session 4
Moderator: Moussa Mansour, MD
Panel: Andrea Natale, MD, Isabel Deisenhofer, MD, Vivek Reddy, MD, Dhanunjaya R. Lakkireddy, MD, and Gregory Michaud, MD

WATCHMAN LAA Closure with 4-D ICE Guidance
Rodney Horton MD and Amin Al-Ahmad, MD (Austin, TX)

Ablation of Atrial Fibrillation Using SPHERE 9 Lattice Tip PFA Catheter
Andrea Sarkozy, MD (Brussels, Belgium)

Ablation of Paroxysmal AF Using a VARIPULSE Variable Loop Circular PFA Catheter – POLARIS Study
Moussa Mansour, MD (Boston, MA)

Disc and Lobe LAA Closure using Amulet with TEE Guidance
Frank Cuoco, MD (Charleston, SC)

Nanosecond Pulsed Field Ablation for AF
Petr Neuzil, MD and Vivek Reddy, MD (New York, NY)

LAA Closure with the LAMINARLAA Device
Devi Nair, MD (Jonesboro, AR)

12:30-1:30 PM Lunch

1:30-2:30 PM
Lesion Assessment in Catheter Ablation for Atrial Fibrillation
Supported by an Educational Grant from Biosense Webster
Moderators: Luigi Di Biase, MD, PhD & Jose Osorio MD
All lectures 7 minutes. Panel Discussion 25 minutes.

Lesion Optimization with a Very High Power Short Duration Force & Temperature Sensing Catheter
Srinivas Dukkipati, MD

Dual Energy Pulsed Field-Radiofrequency Focal Ablation System
Tom De Potter, MD

Utility of Ablation Index with Pulsed Field Ablation
Luigi Di Biase, MD, PhD

Debate: Is Force Sensing Useful and Necessary for Pulsed Field Ablation
Pro: Hiroshi Nakagawa, MD, PhD
Con:
David Haines, MD

Panel and Audience Discussion - All Faculty

2:30-3:30 PM
Optimizing Catheter Ablation for AF - Non-PV Targets
Moderators: Hugh Calkins, MD and Laurent Macle, MD
All lectures 7 minutes. Panel Discussion 25 minutes.

Impact of Ablation of Low Voltage Areas in Persistent AF: STABLE-SR III Study
MinLong Chen, MD

MRI Fibrosis Guided Ablation vs PVI Alone in Young Patients with AF: DECAAF II Substudy
Nassir Marrouche, MD

CAPLA Substudy - AF Frequency and Patient Selection for Posterior Wall Isolation
Jonathan Kalman, MD

Role of Posterior Wall Isolation in AF Ablation - Impact of Pulsed Field Ablation
Andrea Natale, MD

Hybrid Ablation for AF - Current Status and Future in the Era of Pulsed Field Ablation
Kenneth Ellenbogen, MD

Panel and Audience Discussion (25 minutes): All Faculty

3:30-4:00 PM Break

4:00-5:00 PM
Pulsed Field Ablation - New Clinical Trial Evidence
Moderators: Meleze Hocini, MD and Gerhard Hindricks, MD
All lectures 7 minutes. Panel Discussion 25 minutes.

PULSED-AF Study
David DeLurgio, MD

INSPIRE Study
Tom De Potter, MD

ADVENT Study
Moussa Mansour, MD

MANIFEST-PF and MANIFEST-17K
Vivek Reddy, MD

Non-Pulmonary Vein Targets with Pulsed Field Ablation
Melanie Gunawardene, MD

Panel and Audience Discussion – All Faculty

5:00-6:45 PM
Tribute to Albert L. Waldo, MD
Kalyanam Shivkumar, MD, PhD

Late Breaking Clinical Science Session II and Best Abstract Award
Moderators:
Kalyanam Shivkumar, MD, PhD and Angelo Auricchio, MD, PhD
All talks 10 minutes & 5 minutes Q&A

First Experience with the Amulet Occluder in the United States: Early Insights from EMERGE LAA Post-Approval Study
Christopher R. Ellis, MD

Pulmonary Vein Narrowing after Pulsed Field vs Thermal Ablation: A Prespecified Secondary Endpoint of the Randomized ADVENT Trial
Moussa Mansour, MD

Pulsed Field Ablation Using a Variable Loop Circular Catheter with 3D Mapping Integration: Early Outcomes of the admIRE Study
David Newton, MD

Predictors of Success for Pulmonary Vein Isolation with Pulsed Field Ablation Using a Variable Loop Catheter with 3D Mapping Integration: Complete 12-month outcomes from inspire
Vivek Reddy, MD

Long-Term Effects of Pulsed Field Ablation on Coronary Arteries
Yury Malyshev, MD

Left Atrial Appendage Exclusion in Addition to Pulmonary Vein Isolation for
Non-paroxysmal Atrial Fibrillation: Results from the aMAZE Continued Access Protocol (aMAZE CAP)
Dhanunjaya Lakkireddy, MD, MBA

Best Abstract Award

6:45 PM Adjourn

SATURDAY, FEBRUARY 3, 2024

7:30 AM-9:30 AM
Case Transmissions Session 5
Moderator:
Moussa Mansour, MD
Panel:
Pierre Jais, MD, Vivek Reddy, MD, Devi Nair, MD, Gerhard Hindricks, MD and Melanie Gunawardene, MD

Ablation of Paroxysmal AF Using a VARIPULSE Variable Loop Circular PFA Catheter - VIRTUE Study
Vivek Reddy, MD and Srinivas Dukkipati, MD (New York, NY)

PVI and Mitral Isthmus Ablation of Persistent AF Using FARWAVE Pentaspline PFA Catheter
Petr Neuzil, MD, PhD (Prague, Czech Republic)

Ablation of Paroxysmal AF Using OMNYPULSE Novel Large Footprint Focal Force Sensing PFA Catheter
Mattias Duytschaever, MD (Bruges, Belgium)

Pulsed Field Ablation - FIH Experience with the Next Generation Volt PFA System
Prashanthan Sanders, MD, PhD (Adelaide, Australia)

9:30-10 AM: Break

10:00-11:00 AM
Case Transmissions Session 6
Moderator: Moussa Mansour, MD
Panel:
Amin Al Ahmad, MD, Devi Nair, MD, Saumil Oza, MD and Pierre Jais, MD

Ablation of Paroxysmal AF Using the Globe Pulsed Field Ablation Catheter
Devi Nair, MD (Jonesboro, AR)

Electrogram Dispersion Guided Ablation with Volta AF-Xplorer and GE Cardiolab
Saumil Oza, MD (Orange Park, FL)

11:00 AM-12:00 PM
Pulsed Field Ablation - Efficiency and Safety
Moderators: Devi Nair, MD and
Luigi Di Biase, MD, PhD

All lectures 7 minutes. Panel Discussion 25 minutes.

Efficiency of Pulsed Field Ablation - Ease of Use and Comparison with RF Ablation
Ante Anic, MD

General Anesthesia vs Sedation & Other Workflow Considerations for Pulsed Field Ablation
Julian Chun, MD

Coronary Artery Spasm During PFA – Review of Clinical Evidence and Prevention
Edward Gerstenfeld, MD

Safety Considerations with Pulsed Field Ablation - Esophagus, Phrenic N., Cerebral Lesions, & Hemolysis
Thomas Deneke, MD

FDA Policy Update on Evaluation of New Technologies for AF Management
Aneesh Deoras, MSE, Assistant Director for Cardiac Ablation, Mapping, and Imaging Devices, Office of Cardiovascular Devices, CDRH, US FDA

Panel and Audience Discussion – All Faculty

12:00-12:30 PM Working Lunch

12:30-1:30 PM
Pulsed Field Ablation - Optimizing Lesion Delivery and Future Directions in Technology
Moderators:
David Haines, MD and
Pierre Jais, MD

All lectures 7 minutes. Panel Discussion 25 minutes.

Durability of PVI with Pulsed Field Ablation - Results and Significance of Remapping Studies
Devi Nair, MD

Optimizing Pulsed Field Ablation Lesion Parameters
Jacob Koruth, MD

PFA Catheter Designs: Small Tip Focal, Large Tip Focal, and Single Shot
Pierre Jais, MD

First in Human Experience with Novel Pulsed Field Ablation Technologies
Andrea Natale, MD

Future Technologies in Pulsed Field Ablation
Vivek Reddy, MD

Panel and Audience Discussion - All Faculty & Andrew Farb, MD, Chief Medical Officer, Office of Cardiovascular Devices, CDRH, US FDA

1:30-2:30 PM
Spotlight Session II - New and Emerging Technologies in Arrhythmia Management
All lectures 5 minutes.
Moderator: Paul Wang, MD

Universal Zero Exchange Transseptal System (Atraverse Medical)
Usman Siddiqui, MD

Development of True Single Shot PFA with an Ultra-Compliant Balloon (CardioFocus)
Jacob Koruth, MD

AI in the EP Lab: Replacing Legacy EP Recording Standards with ECGenius and AI-Algorithms to Effectively Measure Success of Ablation Outcomes (CathVision)
Larry Chinitz, MD

FieldBending: The Importance Of The Electric Field Geometry In Emerging Ablation Technologies (Field Medical)
Kars Neven, MD, PhD

Sensor-Based PFA and RF Ablation and Optical Mapping (LuxMed Systems)
Jacob Koruth, MD

Optical Sensing to Assess PFA Lesion Permanence (MedLumics)
Atul Verma, MD

Atlas AI in Remote Monitoring (Octagos Health)
Usman Siddiqui, MD

Unlocking Arrhythmias: vMap's AI-Driven Revolution (Vektor Medical)
Jagmeet Singh, MD, PhD

First Preclinical Experience with the EasyPulz Single Shot PFA Multi Electrode Basket Catheter (BTL Medical)
Petr Neuzil, MD, PhD

Protecting the Esophagus with Deviation: "EASY AF" Randomized Study Results. (S4 Medical)
Devi Nair, MD

2:30-3:30
Challenging Cases in AF Management and Stroke Prevention
(7-minute presentation & 5-minute discussion for each case)
Moderator:
David Keane, MD, PhD
Faculty:
John Day, MD, Isabel Deisenhofer, MD, Gerhard Hindricks, MD, Young-Hoon Kim, MD, PhD, and Laurent Macle, MD

3:30 ADJOURN

4:00 - 8:00 PM FELLOWS PROGRAM